The Rosamund Stone Zander Translational Neuroscience Center strives to improve the lives of all children with brain disorders by fostering timely and efficient translational research.
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Harnessing the potential of human induced pluripotent stem cells, functional assays and machine learning for neurodevelopmental disorders
In this review, RSZ TNC researchers compare two-dimensional and three-dimensional human-induced pluripotent stem cell (hiPSC) formats for disease modeling, discuss the applications of functional assays, and offer insights on incorporating machine learning into hiPSC-based neurodevelopmental disorder research and drug screening.
Novel Phenotypes and Genotype-Phenotype Correlations in Patients with Kleefstra Syndrome
A retrospective chart review performed on 65 patients with Kleefstra Syndrome evaluated at the BCH Kleefstra clinic uncovered novel phenotypes and genotype-phenotype correlations. This information may be useful for guiding clinical care and informing future research and therapeutic initiatives.
Rosamund Stone Zander Translational Neuroscience Center Selects Three Pilot Research Grant Awardees
The Rosamund Stone Zander Translational Neuroscience Center (RSZ TNC) at Boston Children’s Hospital is delighted to announce the selection of this year’s RSZ TNC Pilot Research Grant awardees. The mission of the RSZ TNC is to improve the lives of children with brain disorders via timely and efficient translation of scientific research through collaboration with Boston Children’s Hospital’s exceptional investigators, and in partnership with the external research community. To fulfill the goal of “timely and efficient translation,” this grant aims to support translational research on neurodevelopmental disorders within the domains of Preclinical Research, Drug Discovery, Therapeutic Development, Translational Biomarkers, and Gene-based Clinical Research and Trials.