People
RSZ TNC Faculty
Mandana Arbab, PhD
Assistant Professor, Harvard Medical School; Assistant Professor, Harvard University Program in Neuroscience; Faculty, Rosamund Stone Zander Translational Neuroscience Center at Boston Children’s Hospital
Dr. Arbab is focused on understanding and treating causes of neurodegeneration by CRISPR genome editing. She leverages her expertise in genome editing, including Cas-nucleases, base editing, and prime editing, to probe pathogenic mechanisms of genetic neurological diseases in high-throughput cellular assays. She has developed genome editing therapeutics to treat neurodegenerative diseases in cells and in mice, and her lab works to translate these treatments for future use in patients.
Dr. Arbab is the Lodish Family Assistant Professor of Neurology at Harvard Medical School, and faculty member of the Rosamund Stone Zander Translational Neuroscience Center at Boston Children’s Hospital. She received her PhD in Regenerative Medicine at the Hubrecht Institute in The Netherlands, where she specialized in modeling motor neuron diseases. Dr. Arbab completed her postdoctoral fellowship at the Broad Institute with Prof. David Liu on characterizing genome editing outcomes and developing genome editing therapeutics to treat neurological diseases. In 2021, Manda was awarded a Pathway to Independence Award from the NIH National Institute of Neurological Disorders and Stroke.